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CLOSED · 01:15 ET
Market ClerkRecap
Thu Oct 22 · markets closed2 signals on Oct 21108 insider buys this week · $250.3MCIRO short report next: Oct 30The week ahead

SYRE

Spyre Therapeutics, Inc.
NASDAQ · HEALTH CARE · PHARMACEUTICAL PREPARATIONS
92.95
+1.55 +1.70%
USD · close Oct 21

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MKT CAP $8.2BP/E —DIV YIELD —FCF YIELD —REV TTM —NET INCOME −$178.9MNET CASH —52W 22.18 – 108.92NEXT EARNINGS Nov 3 EST.SEC XBRL · TTM TO Invalid Date

Financials

SEC XBRL · 58 PERIODS · WHOLE USD

By quarter

PeriodRevenueYoYGross marginOperating incomeNet incomeYoYEPSOp. cash flowCapexFree cash flowFiled
Q2 2026 · Jun 30———−$41.6M−$36.2M—-0.35−$69.9M——Aug 4
Q1 2026 · Mar 31———−$45.6M−$69M—-0.74−$57.4M——Aug 4
Q4 2025 · Dec 31derived———−$57.2M−$62.5M——−$44.6M——Feb 19
Q3 2025 · Sep 30———−$56.9M−$11.2M—-0.15−$37.1M——Nov 4
Q2 2025 · Jun 30———−$41.9M−$36.7M——−$46.6M——Aug 4
Q1 2025 · Mar 31———−$53.6M−$44.8M——−$41M——Aug 4
Q4 2024 · Dec 31derived$0——−$61.3M−$56.3M——−$37.2M——Feb 19
Q3 2024 · Sep 30$0——−$55.4M−$69M—1.06−$29.4M——Nov 4
Q2 2024 · Jun 30$0——−$44.1M−$38.8M—0.59−$62.2M——Nov 4
Q1 2024 · Mar 31$0——−$47.8M−$43.9M—0.72−$28.5M——Nov 4
Q4 2023 · Dec 31derived$0——−$45.9M−$63.2M—-0.89−$31M$0−$31MFeb 19
Q3 2023 · Sep 30$0——−$18.3M−$40.1M—0.86−$34.6M——Nov 18

By fiscal year

YearRevenueGross marginOperating incomeNet incomeNet marginEPSOp. cash flowCapexFree cash flowBuybacksDividends paid
FY2025 · to Dec 31$0—−$209.6M−$155.2M——−$169.3M————
FY2024 · to Dec 31$0—−$208.6M−$208M——−$157.4M$0−$157.4M——
FY2023 · to Dec 31$886K—−$242.3M−$338.8M-38238.1%13.76−$99.9M$0−$99.9M——
FY2022 · to Dec 31$2.3M—−$84.8M−$83.8M-3598.8%-24.86−$80.1M$38K−$80.2M——
FY2021 · to Dec 31$18.7M—−$65.6M−$65.8M-351.1%-25.02−$53.7M$573K−$54.3M——
FY2020 · to Dec 31$0—−$81.5M−$80.9M—-1.52−$75.8M$4.3M−$80.1M——

Every number comes from Spyre Therapeutics, Inc.'s own XBRL-tagged filings with the SEC, not a data vendor. Quarters marked derived are the fiscal year minus the three reported quarters, the same way every data provider computes Q4. Restated figures replace originals as later filings arrive.

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